Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms,<i>Lentinus edodes</i>and<i>Agaricus blazei</i>, on the Expression of Cytochrome P450s in Mice

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  • HASHIMOTO Takashi
    <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i>
  • NONAKA Yuji
    <i>Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University</i>
  • MINATO Ken-ichiro
    <i>Miyagi Agricultural College</i>
  • KAWAKAMI Sachiko
    <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i> <i>Tottori Mycological Institute</i>
  • MIZUNO Masashi
    <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i>
  • FUKUDA Itsuko
    <i>Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University</i>
  • KANAZAWA Kazuki
    <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i>
  • ASHIDA Hitoshi
    <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i> <i>Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University</i>

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  • Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms, Lentinus edodes and Agaricus blazei, on the Expression of Cytochrome P450s in Mice.

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説明

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.<br>

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