Potent Hypocholesterolemic Activity of the Yeast Kluyveromyces marxianus YIT 8292 in Rats Fed a High Cholesterol Diet
-
- YOSHIDA Yasuto
- Yakult Central Institute for Microbiological Research
-
- YOKOI Wakae
- Yakult Central Institute for Microbiological Research
-
- WADA Yasue
- Yakult Central Institute for Microbiological Research
-
- OHISHI Kenji
- Yakult Central Institute for Microbiological Research
-
- ITO Masahiko
- Yakult Central Institute for Microbiological Research
-
- SAWADA Haruji
- Yakult Central Institute for Microbiological Research
Bibliographic Information
- Other Title
-
- Potent Hypocholesterolemic Activity of the Yeast<i>Kluyveromyces marxianus</i>YIT 8292 in Rats Fed a High Cholesterol Diet
Search this article
Abstract
The hypocholesterolemic activities of 81 yeast strains were examined in rats fed a high cholesterol diet (HCD). Male Wistar rats were fed an HCD or an HCD supplemented with 10% yeast for 7 d. It was found that the hypocholesterolemic activities of the yeasts varied remarkably between strains. Kluyveromyces marxianus YIT 8292 exhibited the most potent hypocholesterolemic activity among the yeasts that were tested. K. marxianus YIT 8292 significantly decreased not only plasma total cholesterol but also liver total cholesterol when administered as a dietary admixture at a concentration of 3%. In contrast, brewer’s yeast and baker’s yeast, which have been predominantly used for food, did not exhibit hypocholesterolemic activity even when administered at a concentration of 10%. These results suggest that K. marxianus YIT 8292 may be utilized as a novel food material with the ability to contribute to the prevention of hypercholesterolemia.
Journal
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 68 (6), 1185-1192, 2004
Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Tweet
Details 詳細情報について
-
- CRID
- 1390282681450018944
-
- NII Article ID
- 10013286250
-
- NII Book ID
- AA10824164
-
- COI
- 1:CAS:528:DC%2BD2cXls1arsrc%3D
-
- ISSN
- 13476947
- 09168451
-
- NDL BIB ID
- 6990733
-
- PubMed
- 15215579
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed