Regulation of Virulence Factors of Enterohemorrhagic <i>Escherichia coli</i> O157:H7 by Self-Produced Extracellular Factors
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- KANAMARU Kyoko
- Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
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- KANAMARU Kengo
- Institute of Molecular and Cellular Biosciences, University of Tokyo
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- TATSUNO Ichiro
- Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
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- TOBE Toru
- Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
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- SASAKAWA Chihiro
- Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
書誌事項
- タイトル別名
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- Regulation of Virulence Factors of Enterohemorrhagic Escherichia coli O157:H7 by Self-Produced Extracellular Factors.
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抄録
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes serious diarrhea and hemolytic uremic syndrome in humans. The expressions of EspD and intimin by O157:H7 have now been shown to be down-regulated by medium conditioned by O157:H7 grown at stationary phase. Preparation of conditioned medium showing the effect on the amount of EspD was not dependent on temperature or growth medium, but was dependent on growth phase. Inhibition of EspD and intimin expression was also induced by medium conditioned by E. coli K-12 strains and homoserine lactone, a signal molecule of the quorum-sensing system in Gram-negative bacteria. These results suggest the possibility that the quorum-sensing system mediated by self-produced extracellular factors plays an important role in control of colonization of EHEC O157:H7.<br>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 64 (11), 2508-2511, 2000
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681450342272
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- NII論文ID
- 110002679852
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3cXos1SrurY%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 5590922
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- PubMed
- 11193429
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可