Enterostatin (VPDPR) and Its Peptide Fragment DPR Reduce Serum Cholesterol Levels after Oral Administration in Mice
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- TAKENAKA Yasuyuki
- <i>Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University</i> Present address: <i>Department of Domestic Science, Kobe Shoin Woman's College</i>
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- NAKAMURA Futoshi
- <i>Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University</i> Present address: <i>R&D; Center, CALPIS Co., Ltd.</i>
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- YAMAMOTO Taichi
- <i>Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University</i> Present address: <i>Kikkoman R&D; division</i>
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- YOSHIKAWA Masaaki
- <i>Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University</i>
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We found that enterostatin (VPDPR), an anorexigenic peptide for a high-fat diet, significantly reduces serum cholesterol levels after oral administration of 100 mg/kg for 3 days in mice fed a high cholesterol-cholic acid diet. DPR, a peptide fragment of VPDPR, also had hypocholesterolemic activity at a dose of 50 mg/kg. Food intake was not suppressed under these dietary conditions. Fecal excretion of cholesterol and bile acids was increased significantly by both VPDPR and DPR. Interestingly, DPR induced hypocholesterolemic effects just two hours after a single oral administration at a dose of 100 mg/kg.<br>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 67 (7), 1620-1622, 2003
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681450444288
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- NII論文ID
- 110002694278
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3sXmtFeks7g%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 6622362
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- PubMed
- 12913316
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 使用不可