Suppressive Effect of Caffeine on Hepatitis and Apoptosis Induced by Tumor Necrosis Factor-.ALPHA., but Not by the Anti-Fas Antibody, in Mice.

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  • SUGIYAMA Kimio
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka, University
  • NODA Yasuhiro
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka, University
  • HE Puming
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka, University

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  • Suppressive Effect of Caffeine on Hepatitis and Apoptosis Induced by Tumor Necrosis Factor-α, but Not by the Anti-Fas Antibody, in Mice
  • Suppressive Effect of Caffeine on Hepatitis and Apoptosis Induced by Tumor Necrosis Factor アルファ but Not by the Anti Fas Antibody in Mice

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Abstract

Tumor necrosis factor (TNF)-α-induced hepatitis and apoptosis, as respectively assessed by serum enzyme activities and hepatic DNA fragmentation were effectively suppressed by a single force-feeding of caffeine (100 mg/kg) 1.5 h before injecting the drug. In contrast, caffeine had no significant effect on anti-Fas antibody-induced hepatitis and apoptosis. These results suggest that caffeine differentially affected TNF-α receptor- and Fas-mediated hepatitis and apoptosis.

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