Effects of 2,3-Diketo-L-gulonic Acid on the Oxidation of Yolk Lipoprotein.
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- LI Meihua
- Institute of Environmental Science for Human Life, Ochanomizu University
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- SUZUKI Emiko
- Department of Human Biological Studies, Ochanomizu University
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- KURATA Tadao
- Institute of Environmental Science for Human Life, Ochanomizu University
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Abstract
2,3-Diketo-L-gulonic acid (DKG) is an important intermediate product of oxidative degradation of L-ascorbic acid (AsA) in both biological and food systems, but the physiological function of DKG is still unclear. In this study, it was found that DKG had a strong antioxidative effect on copper-dependent oxidative modification of yolk lipoprotein (YLP), on the basis of both the decreased electrophoretic mobility and longer lag time of conjugated diene formation in a concentration-dependent manner. DKG is known to be very unstable and easily converts into two δ-lactones of DKG, the 3,4-enediol form of DKG δ-lactone (3,4-DKGL) and 2,3-enediol form of DKG δ-lactone (2,3-DKGL) depending on both pH and temperature. 3,4-DKGL was thought to be the first degradation product of DKG and could play an antioxidative role in the oxidation of lipoproteins induced by copper ion or peroxyl radicals in neutral aqueous solution.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 65 (3), 599-604, 2001
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390282681450500992
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- NII Article ID
- 110002680309
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- NII Book ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3MXisFKqurw%3D
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 5737807
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- PubMed
- 11330674
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed