Effects of Polysaccharides from Rhizomes of Curcuma zedoaria on Macrophage Functions.
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- KIM Kyung Im
- Graduate School of Biotechnology, Korea University
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- SHIN Kwang Soon
- Department of Food Science and Biotechnology, Kyonggi University
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- JUN Woo Jin
- Graduate School of Biotechnology, Korea University
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- HONG Bum Shik
- Graduate School of Biotechnology, Korea University
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- SHIN Dong Hoon
- Graduate School of Biotechnology, Korea University
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- CHO Hong Yon
- Graduate School of Biotechnology, Korea University
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- CHANG Hyo Il
- Graduate School of Biotechnology, Korea University
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- YOO Seong Mo
- Department of Informational Statistics, Korea University
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- YANG Han Chul
- Graduate School of Biotechnology, Korea University
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Abstract
The effects of Curcuma zedoaria, which is used as a condiment, in perfumery, and as a medicine, on immune response were investigated by measuring macrophage-stimulating activity in macrophages and RAW 264.7 cells. In this study, CZ-1 and CZ-1-III, the fractions partially purified from C. zedoaria, had a strong, dose-dependent lysosomal enzyme activity. It was suggested that active portions of CZ-1-III were polysaccharides rather than proteins. Phagocytic activity increased as a similar pattern in both the Gram-negative and Gram-positive bacteria, time-dependently. It was demonstrated that CZ-1-III can augment the oxygen burst response but had an even higher activity in vivo than in vitro. Also a significant increase of H2O2, NO, and TNF-α production was observed. However, the production of TNF-α at the concentration of 1,000 μg/ml decreased. These data suggested that C. zedoaria had macrophage-stimulating activity and the possibility of being used as a biological response modifier.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 65 (11), 2369-2377, 2001
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681450582400
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- NII Article ID
- 110002693295
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- NII Book ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3MXovFOgs70%3D
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 6003798
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- PubMed
- 11791707
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed