Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats
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- LEE Yoon-Bok
- Central Research Institute, Dr. Chung’s Food Co., Ltd. Department of Food Science and Technology and School of Agricultural Biotechnology, Seoul National University
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- LEE Hyong Joo
- Department of Food Science and Technology and School of Agricultural Biotechnology, Seoul National University
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- KIM Kang Sung
- Department of Food and Nutrition, Yong-in University
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- LEE Jae-Yong
- College of Medicine, Hallym University
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- NAM Sang-Yoon
- College of Veterinary Medicine, Chungbuk National University
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- CHEON Sang-Hee
- Central Research Institute, Dr. Chung’s Food Co., Ltd.
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- SOHN Heon-Soo
- Central Research Institute, Dr. Chung’s Food Co., Ltd.
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To examine a potential role for soybean phytoestrogens in postmenopausal bone loss, twenty-four 12-week-old Sprague-Dawley rats were divided randomly into 4 groups and given controlled diets for 16 weeks. The treatment groups were as followed: sham operated, ovariectomized (OVX) control, OVX + isoflavone extract (6.25 g/kg), and OVX + 17β-estradiol (4 mg/kg). OVX treatments reduced femoral and fourth lumbar vertebral bone density and mineral content (p<0.01), decreased uterine weight (p<0.01), accelerated body weight increases (p<0.05), and increased the activities (p<0.01) of both serum alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP). Supplementation with isoflavone prevented the losses of bone density and mineral content caused by OVX (p<0.01). Although both isoflavone and 17β-estradiol exhibited similar bone-sparing ability on the OVX-induced bone loss, the effect of isoflavone was not the same as that of 17β-estradiol on the serum ALP and TRAP, body weight increase, and uterine weight change. We concluded that dietary supplementation with soybean isoflavone can prevent postmenopausal bone loss via a different mechanism of estrogen in OVX rats.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 68 (5), 1040-1045, 2004
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681450603776
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- NII論文ID
- 10013144565
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD2cXkvVCgu7c%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 6957406
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- PubMed
- 15170107
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可