Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from α-Lactalbumin

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  • TSURUKI Takahiro
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
  • YOSHIKAWA Masaaki
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

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タイトル別名
  • Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from .ALPHA.-Lactalbumin
  • Anti Alopecia Effect of Gly Leu Phe an Immunostimulating Peptide Derived from アルファ Lactalbumin

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説明

Gly-Leu-Phe (GLF), an immunostimulating peptide derived from α-lactalbumin, prevented alopecia induced by an anticancer agent etoposide in a neonatal rat model after intraperitoneal injection at a dose of 100 mg/kg for 4 d or oral administration at a dose of 300 mg/kg for 6 d. By microscopic analysis of skin sections, GLF proved to inhibit etoposide-induced loss of hair, thickening of the epidermis, and thinning of the adipocyte layer. The anti-alopecia effect of GLF was inhibited by pyrilamine, a histamine H1 receptor antagonist, suggesting that the anti-alopecia effect is mediated by histamine release.

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