Dose-Dependent Suppression of Tea Catechins with a Galloyl Moiety on Postprandial Hypertriglyceridemia in Rats
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- SUZUKI Yuko
- Central Research Institute
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- UNNO Tomonori
- Central Research Institute
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- KOBAYASHI Makoto
- Central Research Institute
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- NOZAWA Ayumu
- Central Research Institute
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- SAGESAKA Yuko
- Central Research Institute
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- KAKUDA Takami
- Central Research Institute
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Abstract
Tea has long been believed to be a healthy beverage, and its beneficial effects are almost all attributed to catechins. The effect of catechins on postprandial hypertriglyceridemia in rats was investigated in this study. A lipid emulsion administered orally to rats with (−)-epigallocatechin gallate at a dose of 100 mg/kg resulted in the increase in plasma triacylglycerol being significantly inhibited after 1 and 2 h compared to the case without (−)-epigallocatechin gallate. The effect of (−)-epigallocatechin was weaker than that of (−)-epigallocatechin gallate. A tea extract (THEA-FLAN 90S), mainly composed of catechins with a galloyl moiety, dose-dependently suppressed postprandial triacylglycerol after the administration of a lipid emulsion at doses of 50–200 mg/kg. The administration of the tea extract alone at a dose of 200 mg/kg had no effect on the plasma triacylglycerol level. These results strongly suggest that catechins with a galloyl moiety would be promising agents for suppressing dietary fat absorption through the small intestine.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 69 (7), 1288-1291, 2005
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681451204352
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- NII Article ID
- 130000030269
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7378348
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- PubMed
- 16041132
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed