Apolipoprotein A-I of Hyperlipidemia Atherosclerosis Prone (LAP) Quail: cDNA Sequence and Tissue Expression.

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  • IWASAKI Hironori
    Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
  • OKU Hirosuke
    Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
  • TODA Takayoshi
    Department of Clinical Laboratory Medicine, School of Medicine, University of The Ryukyus
  • NASU Tetsuo
    Department of Veterinary Anatomy, Faculty of Agriculture, Miyazaki University
  • ODA Koji
    Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
  • MIYAGI Tsuyoshi
    Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
  • CHINEN Isao
    Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus

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  Apolipoprotein A-I (apo A-I) has an important role in the transport of cholesterol. This study describes the complete nucleotide and deduced amino acid sequence for apo A-I of LAP quail. A full length apo A-I cDNA clone for hyperlipidemia atherosclerosis prone (LAP) quail was isolated from a λgt10 liver cDNA library. The DNA sequence of LAP apo A-I cDNA was similar to that of normal Japanese quail. The deduced amino acid sequence of LAP apo A-I was hence identical to that of normal Japanese quail. LAP apo A-I mRNA is about 1.4 kilobases in length and expressed in a variety of tissues including small intestine, liver, lung, breast muscle, testis, and heart. Although the tissue distribution of apo A-I was similar between strains, LAP quail expressed more apo A-I mRNA than normal Japanese quail in all tissues examined. This tendency was pronounced with the small intestine. Although the concentration of serum apo A-I did not correlate with the tissue expression of mRNA, the observation may suggest that the increased apo A-I expression in LAP strain had some relevance to the susceptibility of this strain to the experimental atherosclerosis.<br>

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