Comparison of Precursor Structures of the GGNG Peptides Derived from the Earthworm<i>Eisenia foetida</i>and the Leech<i>Hirudo nipponia</i>

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  • MINAKATA Hiroyuki
    Suntory Institute for Bioorganic Research
  • IKEDA Tetsuya
    Suntory Institute for Bioorganic Research
  • NAGAHAMA Tomoaki
    Department of Biological Science, Faculty of Science, Hiroshima University
  • OUMI Tomoyuki
    Department of Biological Science, Faculty of Science, Hiroshima University
  • UKENA Kazuyoshi
    Department of Biological Science, Faculty of Science, Hiroshima University
  • MATSUSHIMA Osamu
    Department of Biological Science, Faculty of Science, Hiroshima University
  • KAWANO Tsuyoshi
    Suntory Institute for Bioorganic Research Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University
  • KIMURA Yasuo
    Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University

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  • Comparison of Precursor Structures of the GGNG Peptides Derived from the Earthworm Eisenia foetida and the Leech Hirudo nipponia.

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  Earthworm and leech cDNAs encoding the GGNG peptides, a family of myotropic peptides, were cloned and examined in this study. Both of the predicted precursor proteins are of polyprotein structure and contain several putative peptides distinct from the GGNG peptides. However, the precursors show organizations distinct from each other and no sequence similarity except for the GGNG peptides.<br>

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