Picrodendrins, a New Group of Picrotoxane Terpenoids: Structure-Activity Profile of Action at the GABA<sub>A</sub>Receptor-coupled Picrotoxinin Binding Site in Rat Brain
書誌事項
- タイトル別名
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- Picrodendrins, a New Group of Picrotoxane Terpenoids: Structure-Activity Profile of Action at the GABAA Receptor-coupled Picrotoxinin Binding Site in Rat Brain.
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説明
Seven out of 20 assayed picrotoxane terpenoids inhibited specific binding of [35S] t-butylbicyclophosphorothionate to rat brain membranes, with IC50 values of 0. 0075-6. 0μM. Picrodendrin Q was identified as the most potent compound, being about 27-fold more potent than picrotoxinin. The high activity of picrodendrins A, M, and Q suggests the significance of the spiro α-ethylidene γ-lactone moiety for the interaction of picrodendrins with the GABAA receptor-coupled picrotoxinin binding site.
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 58 (8), 1506-1507, 1994
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681452620160
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- NII論文ID
- 110002677129
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
