Efficient Synthesis of O-Linked Glycopeptide by a Transglycosylation Using Endo .ALPHA.-N-Acetylgalactosaminidase from Streptomyces sp.

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  • Efficient Synthesis of O-Linked Glycopeptide by a Transglycosylation Using Endo α-N-Acetylgalactosaminidase from Streptomyces sp
  • Efficient Synthesis of O Linked Glycopeptide by a Transglycosylation Using Endo アルファ N Acetylgalactosaminidase from Streptomyces sp

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Abstract

Galβ-(1→3)-GalNAc-linked hexapeptide was synthe-sized by a transglycosylation using Galβ-(1→3)-Gal-NAcβ-pNP as a donor and a serine-containing hexapeptide as an acceptor using endo GalNAc-ase from Streptomyces sp.. The Galβ-(1→3)-GalNAc residue was transferred to the hydroxyl group of the serine residue of the peptide. The total yield of the glycopeptide via this process was better than that of the chemoenzymatic method. This process was confirmed to be a versatile method for the synthesis of O-linked glycopeptides.

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