Rapid Degradation of the Silkworm Diapause Hormone by Trypsin and Its Suppression by VAP-map, a Synthetic Analog of the Cuticular Peptide of Silkworm, Bm ACP-6.7(VAP-Peptide).

DOI Web Site Web Site PubMed 被引用文献1件 参考文献25件

この論文をさがす

抄録

Very fast tryptic degradation of the silkworm diapause hormone was found and the degradation pathway was analyzed by moderating the reaction conditions. It proceeded via cleavage at Arg23 and finally at Arg15 of DH. As the C-terminal structure of DH was essential for exhibiting bioactivity, the first cleavage caused rapid inactivation of the hormone. This tryptic digestion was strongly suppressed by adding VAP-map, a synthetic analog of the cuticular peptide of silkmoths, Bm ACP-6.7 (VAP-peptide), which is a natural synergist of DH. VAP-map suppressed the enzymic reaction by interacting with the substrate, but not with the enzyme.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (25)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ