Novel Application of Shochu Distillery By-products to Prophylaxis against Mammary Carcinogenesis Induced by 7,12-Dimethylbenz[a]anthracene in Rats

DOI Web Site Web Site PubMed 7 Citations 29 References
  • SASAKI Taku
    Department of Nutritional Science, Faculty of Applied Biological Science, Tokyo University of Agriculture Department of Medicine, Tokai University School of Medicine
  • ABE Makoto
    Department of Nutritional Science, Faculty of Applied Biological Science, Tokyo University of Agriculture
  • NAKAYAMA Shin’ichi
    Department of Nutritional Science, Faculty of Applied Biological Science, Tokyo University of Agriculture
  • MORIYAMA Kazuyuki
    Kirishima Shuzou Co., Ltd.
  • TAHARA Hidetaka
    Kirishima Shuzou Co., Ltd.
  • TAKITA Toshichika
    Department of Nutritional Science, Faculty of Applied Biological Science, Tokyo University of Agriculture

Bibliographic Information

Other Title
  • Novel Application of<i>Shochu</i>Distillery By-products to Prophylaxis against Mammary Carcinogenesis Induced by 7,12-Dimethylbenz[<i>a</i>]anthracene in Rats

Search this article

Description

The effect of the heat-dried product of Shochu distillery by-products (HSDB) derived from sweet potato on mammary carcinogenesis in rats was investigated. HSDB was fed at 2.5% or 5% of the total feed weight. Dietary HSDB at the 5% level suppressed the incidence and number of tumors, and delayed the latency of mammary tumor development relative to the control diet. Experiments were conducted to determine the relative polarity of the anticarcinogenic constituent(s). The number of tumors per tumor-bearing rat was lower in the diet group fed with an ethyl acetate extract of HSDB than in the control group. The tumor incidence evaluated at both palpation and autopsy was slightly lower in the group fed with a methanol extract than in the control group. These results suggest that HSDB contained at least two constituents of differing polarity that counteracted mammary carcinogenesis.

Journal

Citations (7)*help

See more

References(29)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top