Preparation of Oligosaccharide Units Library and Its Utilization.

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  • Preparation of Oligosaccharide Units Li

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Abstract

There is high current interest in developing synthetic routes to oligosaccharides involved in glycoconjugates. Significant attention has been focused on the application of glycosidase-catalyzed transglycosylation for practical synthesis of oligosaccharides. The enzymatic synthesis has become more practical by the use of several glycosidases available in sufficient quantities. This review desbribes convenient syntheses of di- and trisaccharide units' which are related to molecular recognition, by using regioselective transgalactosylation, trans-N-acetylglucosaminylation, transfucosylation, and transmannosylation. The regioselectivity could be controlled to some extent by using the following techniques: (1) varying enzymed, (2) organic co-solvent system, (3) the configuration of the existing glycosidic linkage of the acceptor and (4) inclusion complex of acceptor glycoside with cyclodextrin. Furthermore, glycopolymers carrying a series of disaccharides containing β-D-galactosyl resideues were synthesized and used as a model in oligosaccharide-lectin interaction analyses. These water-soluble glycopolymers were shown to be useful as probes of carbohydrate recognition.

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