Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells
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- ZHANG Zhongyuan
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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- TERUYA Kiichiro
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Faculty of Agriculture, Kyushu University
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- ETO Hiroshi
- Daiichi Sangyo Co., Ltd.
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- SHIRAHATA Sanetaka
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Faculty of Agriculture, Kyushu University
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Abstract
Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed, has antitumor, anticoagulant, antiviral, anti-inflammatory, and antibacterial activities. Several studies have shown that a fucoidan treatment of cancer cells induced cytotoxicity and apoptosis and inhibited angiogenesis and invasion. We investigated in the present study the effect of low-molecular-weight fucoidan (LMWF) on apoptosis in estrogen receptor-negative MDA-MB-231 human breast cancer cells. The LMWF treatment of MDA-MB-231 cells was associated with the activation of caspases and mitochondrial dysfunction, including dissipation of the mitochondrial membrane potential (ΔΨm), alteration of Ca2+ homeostasis, cytochrome c release, and decreased expression of antiapoptotic Bcl-2 family proteins. Understanding the molecular events that mediated LMWF-induced MDA-MB-231 cell death will contribute to a more rational approach to cancer chemotherapy.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 77 (2), 235-242, 2013
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681453599232
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- NII Article ID
- 10031164721
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- NII Book ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3szmsFKmug%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 024294966
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- PubMed
- 23391903
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed