Soystatin (VAWWMY), a novel bile acid-binding peptide, decreases micellar solubility and inhibits cholesterol absorption in rats

DOI Web Site Web Site PubMed 被引用文献26件 参考文献28件
  • NAGAOKA Satoshi
    Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
  • NAKAMURA Atsushi
    Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
  • SHIBATA Haruhiko
    Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University
  • KANAMARU Yoshihiro
    Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University

書誌事項

タイトル別名
  • Soystatin (VAWWMY), a Novel Bile Acid-Binding Peptide, Decreased Micellar Solubility and Inhibited Cholesterol Absorption in Rats

この論文をさがす

説明

This study was designed to identify a novel peptide derived from soybean protein that induces inhibition of cholesterol absorption in vivo. VAWWMY (Val-Ala-Trp-Trp-Met-Tyr, designated soystatin) had a significantly greater ability to bind bile acid than soybean protein peptic hydrolysate (SPH) or casein tryptic hydrolysate (CTH). Surprisingly, the bile-acid binding ability of VAWWMY was almost as strong as that of the hypocholesterolemic medicine cholestyramine. The micellar solubility of cholesterol was significantly lower in the presence of VAWWMY than in that of SPH or CTH. We found that soystatin derived from soybean glycinin acted as an inhibitor of cholesterol absorption in vivo.

収録刊行物

被引用文献 (26)*注記

もっと見る

参考文献 (28)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ