Greater Effectiveness of .EPSILON.-Viniferin in Red Wine Than Its Monomer Resveratrol for Inhibiting Vascular Smooth Muscle Cell Proliferation and Migration
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- ZGHONDA Nahla
- Graduate School of Life and Environmental Sciences, University of Tsukuba
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- YOSHIDA Shigeki
- Graduate School of Life and Environmental Sciences, University of Tsukuba
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- ARAKI Masahiro
- Graduate School of Life and Environmental Sciences, University of Tsukuba
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- KUSUNOKI Miki
- Graduate School of Life and Environmental Sciences, University of Tsukuba
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- MLIKI Ahmed
- Laboratory of Molecular Physiology of Grapevine, Biotechnology Center
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- GHORBEL Abdelwahed
- Laboratory of Molecular Physiology of Grapevine, Biotechnology Center
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- MIYAZAKI Hitoshi
- Graduate School of Life and Environmental Sciences, University of Tsukuba
Bibliographic Information
- Other Title
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- Greater effectiveness of ε-viniferin in red wine than its monomer resveratrol for inhibiting vascular smooth muscle cell proliferation and migration
- Greater effectiveness of e viniferin in red wine than its monomer resveratrol for inhibiting vascular smooth muscle cell proliferation and migration
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Abstract
Resveratrol is a strong candidate for explaining an irreversible correlation between red wine consumption and coronary heart disease. The present study examined the effect of ε-viniferin, a dehydrodimer of resveratrol, on vascular smooth muscle cells (VSMCs), because ε-viniferin functions are poorly understood in spite of its comparable content to resveratrol in red wines and grapes. Both ε-viniferin and resveratrol inhibited platelet-derived growth factor-induced cell proliferation, migration, and reactive oxygen species (ROS) production, in addition to inducing nitric oxide generation. ε-Viniferin was more effective than resveratrol in these effects, except for inhibiting ROS production. The compounds also increased the expression of the antioxidant enzyme, hemeoxygenase-1, via transcription factor Nrf2. The phosphatidylinositol 3-kinase-Akt pathway was implicated in resveratrol-dependent nuclear Nrf2 accumulation, whereas extracellular signal-regulated kinase and p38 were involved in ε-viniferin-induced Nrf2 accumulation. These data suggest that ε-viniferin may function more effectively than resveratrol in different mechanisms and cooperatively with resveratrol in preventing atherosclerosis.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (7), 1259-1267, 2011
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390282681453657472
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- NII Article ID
- 10029328919
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 11174207
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- PubMed
- 21737923
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed