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- MIYAZAWA Mitsuo
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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- NAKANISHI Kyousuke
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
書誌事項
- タイトル別名
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- Biotransformation of (-)-Menthone by Human Liver Microsomes
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説明
The aim of the current study was to investigate the metabolism of (−)-menthone by liver microsomes of humans. (−)-Menthone (1) was metabolized to (+)-neomenthol (2) (3-reduction) and 7-hydroxymenthone (3) by human liver microsomes. The metabolites formed were analyzed on GC and GC–MS. Kinetic analysis showed that Km and Vmax values for the metabolized (−)-menthone to respective (+)-neomenthol and 7-hydroxymenthone by liver microsomes of human sample HG70 were 0.37 mM and 4.91 nmol/min/mg protein and 0.07 mM and 0.71 nmol/min/mg protein.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (5), 1259-1261, 2006
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681453711744
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- NII論文ID
- 10018531679
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 7926528
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可