Biotransformation of (−)-Menthone by Human Liver Microsomes

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  • MIYAZAWA Mitsuo
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
  • NAKANISHI Kyousuke
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

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  • Biotransformation of (-)-Menthone by Human Liver Microsomes

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The aim of the current study was to investigate the metabolism of (−)-menthone by liver microsomes of humans. (−)-Menthone (1) was metabolized to (+)-neomenthol (2) (3-reduction) and 7-hydroxymenthone (3) by human liver microsomes. The metabolites formed were analyzed on GC and GC–MS. Kinetic analysis showed that Km and Vmax values for the metabolized (−)-menthone to respective (+)-neomenthol and 7-hydroxymenthone by liver microsomes of human sample HG70 were 0.37 mM and 4.91 nmol/min/mg protein and 0.07 mM and 0.71 nmol/min/mg protein.

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