Hepatoprotective Effects of Whey Protein on<scp>D</scp>-Galactosamine-Induced Hepatitis and Liver Fibrosis in Rats
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- KUME Hisae
- Department of Nutritional Research, Food Science Institute, Meiji Dairies Corporation
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- OKAZAKI Keiko
- Department of Nutritional Research, Food Science Institute, Meiji Dairies Corporation
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- SASAKI Hajime
- Department of Nutritional Research, Food Science Institute, Meiji Dairies Corporation
書誌事項
- タイトル別名
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- Hepatoprotective Effects of Whey Protein on D-Galactosamine-Induced Hepatitis and Liver Fibrosis in Rats
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The hepatoprotective effects of whey protein on two injections of D-galactosamine (300 mg/kg, i.p.) were investigated in rats fed a modified AIN-93M diet formulated with a protein source of casein or whey for 16 d. The whey protein-containing diet clearly suppressed an increase in plasma alanine and aspartate aminotransferase activity, lactate dehydrogenase and bilirubin, which are hepatitis markers, and also hyaluronic acid, a fibrosis marker. In addition, it suppressed histopathological signs of portal fibrosis, bile duct proliferation, and perivenular sclerosis. These results suggest that supplementation with whey protein can help prevent the development of hepatitis and portal fibrosis.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (5), 1281-1285, 2006
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681453712896
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- NII論文ID
- 10018531764
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 7926651
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可