Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans
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- YAMAUCHI Satoshi
- Faculty of Agriculture, Ehime University
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- SUGAHARA Takuya
- Faculty of Agriculture, Ehime University
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- NAKASHIMA Yuki
- Faculty of Agriculture, Ehime University
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- ABE Koki
- Faculty of Agriculture, Ehime University
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- HAYASHI Yoshimasa
- Faculty of Agriculture, Ehime University
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- AKIYAMA Koichi
- Integrated Center for Sciences, Ehime University
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- KISHIDA Taro
- Faculty of Agriculture, Ehime University
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- MARUYAMA Masafumi
- Faculty of Agriculture, Ehime University
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Abstract
The cytotoxic activity for colon 26 cell line of matairesinol, oxidized matairesinol, 9,9′-epoxylignan and oxidized 9,9′-epoxylignan were examined. (−)-Matairesinol (Mat 1) showed greatest cytotoxic activity (LC50=9 μg/ml) of the lactone-type lignans. 7,7′-Oxomatairesinol having same steric configuration as that of (−)-matairesinol showed greater activity (LC50=25 μg/ml) than hydroxy or mono-oxomatairesinol. The activities of 9,9′-epoxylignan and 7,7′-oxo-9,9′-epoxylignan having same steric configurations as (−)-matairesinol were weaker than that of corresponding matairesinols. Different activity levels were observed between enantiomers.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (12), 2942-2947, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681453782528
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- NII Article ID
- 10018523805
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 8596492
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
