Vitamin D Receptor Is Not Essential for Extracellular Signal-Related Kinase Phosphorylation by Vitamin D<sub>3</sub> in Human Caco-2/TC7 Cells

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  • YAMAUCHI Jun
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition
  • SEKIGUCHI Mariko
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition
  • SHIRAI Tomomi
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition
  • ISHIMI Yoshiko
    Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition

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  • Vitamin D Receptor Is Not Essential for Extracellular Signal-Related Kinase Phosphorylation by Vitamin D₃ in Human Caco-2/TC7 Cells

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Vitamin D3 initiated rapid extracellular signal-related kinase (ERK) phosphorylation, but the contribution of vitamin D receptor (VDR) to this event is unclear. We investigated the use of RNA interference (RNAi) to knockdown VDR. RNAi downregulated VDR as well as its targeted gene expression, but vitamin D3 dependent ERK phosphorylation remained. Thus VDR might not be involved in ERK phosphorylation by vitamin D3.

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