Effects of<i>xapA</i>and<i>guaA</i>Disruption on Inosine Accumulation in<i>Escherichia coli</i>

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  • Effects of xapA and guaA Disruption on Inosine Accumulation in Escherichia coli

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A xapA-disrupted mutant was studied to minimize hypoxanthine production and to improve inosine productivity in mutants of Escherichia coli. The xapA-disrupted mutant accumulated 5.6 g/l of inosine from 40 g/l of glucose, while the parent strain accumulated 4.6 g/l. This result indicates that xapA is activated in xapA-positive inosine-producers and that xapA disruption might be useful for improving inosine productivity.

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