Higher Hypochlorous Acid Scavenging Activity of Ethyl Pyruvate Compared to Its Sodium Salt
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- OLEK Robert Antoni
- Department of Biochemistry, Academy of Physical Education and Sport Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk
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- ZIOLKOWSKI Wieslaw
- Department of Biochemistry, Academy of Physical Education and Sport Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk
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- KACZOR Jan Jacek
- Department of Biochemistry, Academy of Physical Education and Sport Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk
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- WIERZBA Tomasz Henryk
- Department of Physiology, Medical University of Gdansk
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- ANTOSIEWICZ Jedrzej
- Department of Biochemistry, Academy of Physical Education and Sport Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk
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Although a number of studies have focused on the higher ethyl pyruvate antioxidative activity than its sodium salt under various stress conditions, and the greater protective properties of the ester form have been suggested as the effect of better cell membrane penetration, the molecular mechanism has remained unclear. The aim of the present study was therefore to compare the antioxidative activities of sodium and ethyl pyruvate under in vitro conditions by using a liver homogenate as the model for cell membrane transport deletion. The potential effect of ethanol was also evaluated, and hypochlorous acid was used as an oxidant. Our data indicate the concentration-dependent scavenging potency of both sodium and ethyl pyruvate, with the ester having higher activity. This effect was not related to the presence of ethanol. Better protection of the liver homogenate by ethyl pyruvate was also apparent, despite the fact that cell membrane transport was omitted.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (3), 500-504, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681453849344
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- NII論文ID
- 10028201693
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 11051621
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可