Differences in Hepatic Gene Expression as a Major Distinguishing Factor between Korean Native Pig and Yorkshire

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  • KIM Seung-Soo
    College of Life Sciences and Biotechnology, Korea University
  • KIM So-Ra
    College of Life Sciences and Biotechnology, Korea University
  • KIM Jung-Rok
    College of Life Sciences and Biotechnology, Korea University
  • MOON Jin-Kyoo
    College of Life Sciences and Biotechnology, Korea University
  • CHOI Bong-Hwan
    Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration
  • LEE Jae-Won
    Department of Statistics, College of Political Science and Economics, Korea University
  • KIM Kwan-Suk
    Department of Animal Science, Chungbuk National University
  • KIM Tae-Hun
    Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration
  • KIM Hyun-Jung
    College of Pharmacy, Chung-Ang University
  • LEE Cheol-Koo
    College of Life Sciences and Biotechnology, Korea University

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There are phenotypic differences between Korean native pig (KNP) and Yorkshire (YS) breeds due to different interests in selection. YS has been selected for industrial interests such as a growth rate and lean meat production, while KNP has been maintained as a regional breed with local interests such as disease resistance and fat content in and between muscle. A comparison of gene expression profiles from liver tissue reflected overall long-term effects of artificial selection for these two pig breeds. Based on minimum positive false discovery rate (less than 10%) and fold change (|FC|>1.5), 73 differentially expressed genes (DEGs) were identified. Functional analysis of these DEGs indicated clear distinctions in signaling capacity related to epidermal growth factor (EGF), extracellular structure, protein metabolism, and detoxification. Hepatic DEGs demonstrated the importance of hormonal and metabolic capabilities to differences between these two pig breeds.

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