A Detoxified Extract of<i>Rhus verniciflua</i>Stokes Upregulated the Expression of BDNF and GDNF in the Rat Brain and the Human Dopaminergic Cell Line SH-SY5Y

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  • SAPKOTA Kumar
    Department of Biotechnology, Chosun University Central Department of Zoology, Tribhuvan University
  • KIM Seung
    Department of Alternative Medicine, Gwangju University
  • KIM Myung-Kon
    Department of Bio-Food Technology, Chonbuk National University
  • KIM Sung-Jun
    Department of Biotechnology, Chosun University BK21 Research Team for Protein Activity Control, Chosun University

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  • A Detoxified Extract of Rhus verniciflua Stokes Upregulated the Expression of BDNF and GDNF in the Rat Brain and the Human Dopaminergic Cell Line SH-SY5Y

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Rhus verniciflua Stokes (RVS) has traditionally been used as a food supplement and a traditional herbal medicine for centuries in Korea. This study attempted to evaluate the effects of RVS on the expression of Brain derived neurotrophic factor (BDNF) and Glial cell line-derived neurotrophic factor (GDNF) in SH-SY5Y cells and the rat brain. The results indicated that RVS is a potent inducer of Neurotrophic factor (NTF) production both in vitro and in vivo. Treatment with 10 μg/ml and 10 mg/kg RVS for 4 h of SH-SY5Y cells and rats yielded significant increases in BDNF and GDNF protein levels. We also detected BDNF and GDNF immunoreactive neurons in the rat brain. Both BDNF and GDNF-immunohistochemical staining was markedly enhanced in the animals treated with RVS. These results suggest that RVS serves as an ideal adjuvant in regard to regulating NTF expression, and can contribute to neuroprotection in neurodegenerative diseases.

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