Enhanced Immunomodulatory Activity and Stability in Simulated Digestive Juices of Lactobacillus plantarum L-137 by Heat Treatment
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- FUJIKI Takashi
- Food Science Research Center, House Wellness Foods Corporation Food Science Research Center, House Wellness Foods Corporation
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- HIROSE Yoshitaka
- Food Science Research Center, House Wellness Foods Corporation Food Science Research Center, House Wellness Foods Corporation
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- YAMAMOTO Yoshihiro
- Food Science Research Center, House Wellness Foods Corporation Food Science Research Center, House Wellness Foods Corporation
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- MUROSAKI Shinji
- Food Science Research Center, House Wellness Foods Corporation Food Science Research Center, House Wellness Foods Corporation
書誌事項
- タイトル別名
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- Enhanced Immunomodulatory Activity and Stability in Simulated Digestive Juices of <i>Lactobacillus plantarum</i> L-137 by Heat Treatment
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This study reports the effect of heat treating Lactobacillus plantarum L-137 on its in vitro cytokine-inducing activity, on the stability of this activity in simulated digestive juices, and on its in vivo immunomodulatory properties. L-137 cells were harvested at the stationary phase with or without the subsequent heat treatment and then lyophilized. Heat-killed L-137 cells stimulated mouse spleen cells to produce more interleukin-12p40 than unheated L-137. The interleukin-12p40-inducing activity of unheated L-137 was significantly lower when incubated with simulated intestinal juice, but the activity of heat-killed L-137 cells was maintained. Furthermore, heat-killed L-137 was more protective than unheated L-137 in a mouse model of dextran sulfate sodium-induced colitis. A heat treatment may therefore be effective for enhancing the immunomodulatory activity of L-137 cells.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 76 (5), 918-922, 2012
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681454326272
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- NII論文ID
- 10030752637
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC38jltlOgtg%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 023681873
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- PubMed
- 22738959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可