Change in Mutagenic Activity of Genistein after a Nitrite Treatment

DOI Web Site Web Site PubMed 参考文献42件
  • MASUDA Shuichi
    School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka
  • SHIMAMURA Yuko
    School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka
  • KATO Tatsuya
    School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka
  • YU-FENG Tan
    Zhejiang Academy of Medical Sciences Zhejiang Academy of Medical Sciences
  • IWAMOTO Ken-ichi
    School of Pharmaceutical Sciences, University of Shizuoka School of Pharmaceutical Sciences, University of Shizuoka
  • KINAE Naohide
    School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka

この論文をさがす

抄録

This study examined the mutagenic activity of genistein after a nitrite treatment under acidic conditions. Nitrite-treated genistein exhibited mutagenic activity toward Salmonella typhimurium strains TA 100 and TA 98 with or without S9 mix. Nitrite-treated genistein was demonstrated by electron spin resonance to generate radicals. An instrumental analysis showed 3'-nitro-genistein to have been formed in the reaction mixture. However, 3'-nitro-genistein did not exhibit mutagenic activity toward the S. typhimurium strains, suggesting that other mutagens might also have been formed in the reaction mixture. The clastogenic properties of nitrite-treated genistein and 3'-nitro-genistein were examined by a micronucleus test with male ICR mice. Nitrite-treated genistein and 3'-nitro-genistein showed a significantly higher frequency of micronucleated reticulocytes in mice than in the control group. These results suggest that a daily oral intake of genistein and nitrite through foodstuffs might induce the formation of various mutagenic compounds in the body.

収録刊行物

参考文献 (42)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ