Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats

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  • ZHENG Surina
    Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University
  • SANADA Hiroo
    Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University
  • DOHI Hirofumi
    Graduate School of Advanced Integration Science, Chiba University Graduate School of Advanced Integration Science, Chiba University
  • HIRAI Shizuka
    Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University
  • EGASHIRA Yukari
    Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University Laboratory of Food and Nutrition, Graduate School of Horticulture, Chiba University

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タイトル別名
  • Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on <small>D</small>-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats
  • Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on<scp>D</scp>-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats

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We investigated in this study the effect of modified arabinoxylan from rice bran (MGN-3) and its fractions on D-galactosamine (D-GalN)-induced IL-18 expression and hepatitis in rats. Male Wistar rats were pretreated with MGN-3 or fractions of the MGN-3 hydrolysate, or with saline 1 h before administering D-GalN (400 mg/kg B.W.). The serum transaminase activities, IL-18 mRNA expression level in the liver and IL-18 concentration in the serum were determined 24 h after injecting D-GalN. Both the oral and intraperitoneal administration of MGN-3 (20 mg/kg B.W.) alleviated D-GalN-induced hepatic injury under these experimental conditions. The low-molecular-weight fraction (LMW) of MGN-3 showed the strongest protective effect on D-GalN-induced liver injury, its main sugar component being glucose. Moreover, the D-GalN-induced IL-18 expression was significantly reduced by treating with MGN-3 and LMW. The results suggest that MGN-3 and LMW could provide significant protection against D-GalN liver injury, and that IL-18 might be involved in their protective influence.

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