Hepatic Oxidoreduction-Related Genes Are Upregulated by Administration of Hydrogen-Saturated Drinking Water

  • NAKAI Yuji
    Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • SATO Bunpei
    MiZ Co., Ltd.
  • USHIAMA Shota
    Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • OKADA Shinji
    Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • ABE Keiko
    Graduate School of Agricultural and Life Sciences, The University of Tokyo Food Safety and Reliability Project, Kanagawa Academy of Science and Technology
  • ARAI Soichi
    Food Safety and Reliability Project, Kanagawa Academy of Science and Technology Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

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The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.

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