A <i>Caenorhabditis elegans</i> Insulin-Like Peptide, INS-17: Its Physiological Function and Expression Pattern

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  • MATSUNAGA Yohei
    Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University
  • NAKAJIMA Kensuke
    Department of Bioresource Sciences, Faculty of Agriculture, Tottori University Department of Bioresource Sciences, Faculty of Agriculture, Tottori University
  • GENGYO-ANDO Keiko
    Department of Physiology, Tokyo Women's Medical University School of Medicine CREST, JST Department of Physiology, Tokyo Women's Medical University School of Medicine CREST, JST
  • MITANI Shohei
    Department of Physiology, Tokyo Women's Medical University School of Medicine CREST, JST Department of Physiology, Tokyo Women's Medical University School of Medicine CREST, JST
  • IWASAKI Takashi
    Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University Department of Bioresource Sciences, Faculty of Agriculture, Tottori University Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University Department of Bioresource Sciences, Faculty of Agriculture, Tottori University
  • KAWANO Tsuyoshi
    Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University Department of Bioresource Sciences, Faculty of Agriculture, Tottori University Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Tottori University Department of Bioresource Sciences, Faculty of Agriculture, Tottori University

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  • A Caenorhabditis elegans Insulin-Like Peptide, INS-17 : Its Physiological Function and Expression Pattern

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Abstract

The insulin/insulin-like growth factor-1 signaling pathway of Caenorhabditis elegans regulates larval diapause and adult lifespan through the sole insulin receptor-like protein, DAF-2. In the present study, the physiological function and expression pattern of INS-17, one of the C. elegans insulin-like peptides, were examined by disruption and overexpression of the gene, and by the use of a reporter gene. INS-17 might function as a DAF-2 antagonist in the regulation of larval diapause, but not of the adult lifespan. The reporter protein was intensively expressed during larval diapause. It showed a drastic decrease in amount after larval diapause, which matches well the physiological function of INS-17.

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