Important Role of β₁-Integrin in Fucoidan-Induced Apoptosis via Caspase-8 Activation

DOI Web Site PubMed 被引用文献6件 参考文献51件
  • YAMASAKI Yumi
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University Department of Biochemistry and Applied BioScience, Faculty of Agriculture, University of Miyazaki Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University Department of Biochemistry and Applied BioScience, Faculty of Agriculture, University of Miyazaki
  • YAMASAKI Masao
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, University of Miyazaki Department of Biochemistry and Applied BioScience, Faculty of Agriculture, University of Miyazaki
  • TACHIBANA Hirofumi
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • YAMADA Koji
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University

書誌事項

タイトル別名
  • Important Role of β<sub>1</sub>-Integrin in Fucoidan-Induced Apoptosis <i>via</i> Caspase-8 Activation
  • Important role of beta1-integrin in fucoidan-induced apoptosis via caspase-8 activation

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抄録

Fucoidan induces apoptosis by activating caspase-8 in human MCF-7 breast cancer cells, but the detailed mechanism for this is not understood. We demonstrate here that fucoidan interacted with the cell surface, and silencing the β1-integrin gene expression inhibited fucoidan-induced apoptosis accompanied by caspase-8 activation. Fucoidan induced formation of the β1-integrin-caspase-8 complex. These data indicate that β1-integrin is an important factor for the cell-surface binding of fucoidan and plays an important role in fucoidan-induced apoptosis. Fucoidan also induced recruitment of caspase-8 to the β1-integrin intracellular domain, cleaved it into the activated protein by direct combination with β1-integrin, and induced apoptosis via the caspase cascade in MCF-7 cells.

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