Induction by Fructose Force-Feeding of Histone H3 and H4 Acetylation at Their Lysine Residues around the Slc2a5 Gene and Its Expression in Mice

  • HONMA Kazue
    Laboratory of Nutritional Physiology, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences
  • MOCHIZUKI Kazuki
    Laboratory of Nutritional Physiology, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences Research Branch of Food and Nutritional Sciences, Department of Local Produce and Food Sciences, Faculty of Life and Environmental Sciences, University of Yamanashi
  • GODA Toshinao
    Laboratory of Nutritional Physiology, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences

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  • Induction by Fructose Force-Feeding of Histone H3 and H4 Acetylation at Their Lysine Residues around the <i>Slc2a5</i> Gene and Its Expression in Mice

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It has been reported that fructose force-feeding rapidly induced jejunal Slc2a5 gene expression in rodents. We demonstrate in this study that acetylation at lysine (K) 9 of histone H3 and acetylation at K5 and K16 of histone H4 were more enhanced in the promoter/enhancer to transcribed regions of the Slc2a5 gene in fructose force-fed mice than in glucose force-fed mice. However, fructose force-feeding did not induce acetylation at K14 of histone H3, or at K8 and K12 of histone H4 around the Slc2a5 gene. These results suggest that fructose force-feeding induced selective histone acetylation, particularly of H3 and H4, around the jejunal Slc2a5 gene in mice.

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