Aleuria aurantia Lectin Exhibits Antifungal Activity against Mucor racemosus

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  • AMANO Koh
    Graduate School of Science and Technology, Chiba University Graduate School of Science and Technology, Chiba University
  • KATAYAMA Hiroe
    Graduate School of Science and Technology, Chiba University Graduate School of Science and Technology, Chiba University
  • SAITO Akihiro
    Graduate School of Science and Technology, Chiba University Graduate School of Science and Technology, Chiba University
  • ANDO Akikazu
    Graduate School of Science and Technology, Chiba University Graduate School of Science and Technology, Chiba University
  • NAGATA Yoshiho
    Graduate School of Science and Technology, Chiba University Graduate School of Science and Technology, Chiba University

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  • <i>Aleuria aurantia</i> Lectin Exhibits Antifungal Activity against <i>Mucor racemosus</i>

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Aleuria aurantia lectin (AAL) is an L-fucose-specific lectin produced in the mycelia and fruit-bodies of the widespread ascomycete fungus Aleuria aurantia. It is extensively used in the detection of fucose, but its physiological role remains unknown. To investigate this, we analyzed the interaction between AAL and, a zygomycete fungus Mucor racemosus, which is assumed to contain fucose in its cell wall. AAL specifically bound to the hyphae of M. racemosus, because binding was inhibited by L-fucose but not by D-fucose. It inhibited the growth of the fungus at 1 µM, and the M. racemosus cells were remarkably disrupted at 7.5 µM. In contrast, two other fucose-specific lectins, Anguilla anguilla agglutinin and Ulex europaeus agglutinin, did not inhibit the growth of M. racemosus. These results suggest that the growth inhibition activity is unique to AAL, and that AAL could act as an antifungal protein in natural ecosystems.

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