Six New Chalcones from <i>Angelica keiskei</i> Inducing Adiponectin Production in 3T3-L1 Adipocytes

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  • OHNOGI Hiromu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Takara Bio Inc. Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Takara Bio Inc.
  • KUDO Yoko
    Takara Bio Inc. Takara Bio Inc.
  • TAHARA Kenichi
    Takara Bio Inc. Takara Bio Inc.
  • SUGIYAMA Katsumi
    Takara Bio Inc. Takara Bio Inc.
  • ENOKI Tatsuji
    Takara Bio Inc. Takara Bio Inc.
  • HAYAMI Shoko
    Takara Bio Inc. Takara Bio Inc.
  • SAGAWA Hiroaki
    Takara Bio Inc. Takara Bio Inc.
  • TANIMURA Yuko
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine
  • AOI Wataru
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Laboratory of Health Science, Kyoto Prefectural University Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Laboratory of Health Science, Kyoto Prefectural University
  • NAITO Yuji
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine
  • KATO Ikunoshin
    Takara Bio Inc. Takara Bio Inc.
  • YOSHIKAWA Toshikazu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine

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  • Six New Chalcones from Angelica keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes

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Abstract

Angelica keiskei (Ashitaba in Japanese), a traditional herb in Japan, contains abundant prenylated chalcones. It has been reported that the chalcones from A. keiskei showed such bioactivities as anti-bacterial, anti-cancer and anti-diabetic effects. Xanthoangelol, 4-hydroxyderricin and six new chalcones were isolated in this study from an ethanol extract of A. keiskei by octadecyl silyl (ODS) and silica gel chromatography, and identified by 1D- and 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. The chalcones from A. keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome.

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