Effective Cytochrome P450 (CYP) Inhibitors Isolated from Tarragon (Artemisia dracunculus)

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  • BRAHMI Zeineb
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • KATHO Tatsuya
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • HATSUMATA Rie
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • HIROI Asako
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • MIYAKAWA Nami
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • YAKOU Emi
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • SUGAYA Kouichi
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • ONOSE Jun-ichi
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
  • ABE Naoki
    Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture

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  • Effective Cytochrome P450 (CYP) Inhibitors Isolated from Tarragon (<i>Artemisia dracunculus</i>)

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Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC50 values of 10.0 ± 1.3 µM for compound 1 and 3.3 ± 0.2 µM for compound 2, and exhibited mechanism-based inhibition. This is the first reported isolation of effective CYP inhibitors from tarragon (Artemisia dracunculus) purchased from a Japanese market.

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