Characterization of the C-Terminal Diglycine Motif of SUMO-1/3

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  • YAMADA Koji
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University
  • MURAMATSU Miyuki
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University
  • SAITO Daiki
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University
  • SATO-OKA Mai
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University
  • SAITO Masayuki
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University
  • MORIYAMA Taishi
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University
  • SAITOH Hisato
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of New Frontier Sciences, Graduate School of Science and Technology, Kumamoto University Global COE (Centers of Excellence) Program, Global Initiative Center for Pulsed Power Engineering, Kumamoto University Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University Department of New Frontier Sciences, Graduate School of Science and Technology, Kumamoto University Global COE (Centers of Excellence) Program, Global Initiative Center for Pulsed Power Engineering, Kumamoto University

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A hallmark of small ubiquitin-related modifier (SUMO) is the production of a C-terminal tail containing diglycines (GGs), which are believed to be required for SUMOylation. Whether GGs are required components in SUMOylation remains unanswered experimentally. In this study we found that the SUMO-1/3-AA/-GS/-GN/-GA mutant can form sodium dodecyl sulfate (SDS)-dithiothreitol (DTT)-resistant complexes with cellular proteins, indicating that the GG motif is not strictly required for SUMOylation.

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