Extension of Chronological Lifespan by ScEcl1 Depends on Mitochondria in Saccharomyces cerevisiae

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  • AZUMA Kenko
    Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University
  • OHTSUKA Hokuto
    Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University
  • MURAKAMI Hiroshi
    Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University
  • AIBA Hirofumi
    Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University

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  • Extension of Chronological Lifespan by <i>Sc</i>Ecl1 Depends on Mitochondria in <i>Saccharomyces cerevisiae</i>

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Ecl1, a product of the YGR146C gene in Saccharomyces cerevisiae, was identified as a factor involved in chronological lifespan. In this study we found evidence that the function of Ecl1 in the extension of chronological lifespan is dependent on mitochondrial function. The respiratory activity of cells increased when Ecl1 was overexpressed or cells were grown under calorie restriction, but there was no additive effect of calorie restriction and Ecl1 overexpression on increases in respiratory activity or on the extension of chronological lifespan. Based on these results, we propose that overexpression of Ecl1 has same effect as caloric restriction and that its function also depends on mitochondria, just like caloric restriction.

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