Vba5p, a Novel Plasma Membrane Protein Involved in Amino Acid Uptake and Drug Sensitivity in Saccharomyces cerevisiae

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  • SHIMAZU Masamitsu
    Division of Applied Sciences, Graduate School of Engineering, Muroran Institute of Technology Division of Applied Sciences, Graduate School of Engineering, Muroran Institute of Technology
  • ITAYA Teruhiro
    Division of Applied Sciences, Graduate School of Engineering, Muroran Institute of Technology Division of Applied Sciences, Graduate School of Engineering, Muroran Institute of Technology
  • PONGCHAROEN Pongsanat
    Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University
  • SEKITO Takayuki
    Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University
  • KAWANO-KAWADA Miyuki
    Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University Integrated Center for Sciences (INCS), Ehime University Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University Integrated Center for Sciences (INCS), Ehime University
  • KAKINUMA Yoshimi
    Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University Integrated Center for Sciences (INCS), Ehime University Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University Integrated Center for Sciences (INCS), Ehime University

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  • Vba5p, a Novel Plasma Membrane Protein Involved in Amino Acid Uptake and Drug Sensitivity in <i>Saccharomyces cerevisiae</i>

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Vba5p is closest to Vba3p in the vacuolar transporter for basic amino acids (VBA) family of Saccharomyces cerevisiae. We found that green fluorescence protein (GFP)-tagged Vba5p localized exclusively to the plasma membrane. The uptake of lysine and arginine by whole cells was little affected by deletion of the VBA5 gene, but was stimulated by overexpression of the VBA5 gene. The inhibitory effect of 4-nitroquinoline N-oxide on cell growth was accelerated by expression of the VBA5 gene, and was lessened by the addition of arginine. These results suggest that Vba5p is a plasma membrane protein involved in amino acid uptake and drug sensitivity.

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