Identification of Novel Nuclear Protein Interactions with the N-Terminal Part of Filamin A

  • QIU Hao
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • NOMIYAMA Ryosuke
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • MORIGUCHI Keisuke
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • FUKADA Takashi
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • SUGIMOTO Kenji
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University

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Since certain missense mutations in the N-terminal part of filamin A (FLNA) cause inherited skeletal malformation, we screened for proteins that bind to this part of FLNA. We identified two nuclear proteins that are specifically associated with the N-terminal region of FLNA. This suggests more extensive nuclear function of filamin than expected.

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