Glycogen synthase kinase-3β inhibition of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum)

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  • YOSHIDA Jun
    The United Graduate School of Agricultural Sciences, Iwate University
  • NOMURA Satomi
    Faculty of Agriculture, Iwate University
  • NISHIZAWA Naoyuki
    The United Graduate School of Agricultural Sciences, Iwate University Faculty of Agriculture, Iwate University
  • ITO Yoshiaki
    The United Graduate School of Agricultural Sciences, Iwate University Faculty of Agriculture, Iwate University
  • KIMURA Ken-ichi
    The United Graduate School of Agricultural Sciences, Iwate University Faculty of Agriculture, Iwate University

書誌事項

タイトル別名
  • Glycogen Synthase Kinase-3.BETA. Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica Matsum)
  • Glycogen synthase kinase 3 v inhibition of 6 methylsulfinyl hexyl isothiocyanate derived from wasabi Wasabia japonica Matsum
  • Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (<i>Wasabia japonica</i>Matsum)

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抄録

A new biological activity of 6-(methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β. The most potent isothiocyanate, 9-(methylsulfinyl)hexyl isothiocyanate, inhibited glycogen synthase kinase-3β at a Ki value of 10.5 μM and showed ATP competitive inhibition. The structure-activity relationship revealed an inhibitory potency of methylsulfinyl isothiocyanate dependent on the alkyl chain length and the sulfoxide, sulfone, and/or the isothiocyanate moiety.

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