Glioperazine B, as a New Antimicrobial Agent against<i>Staphylococcus aureus</i>, and Glioperazine C: Two New Dioxopiperazines from<i>Bionectra byssicola</i>

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  • ZHENG Chang-Ji
    Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology
  • KIM Young-Ho
    Chungnam National University, College of Pharmacy
  • KIM Won-Gon
    Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology

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  • Glioperazine B, as a New Antimicrobial Agent against Staphylococcus aureus, and Glioperazine C: Two New Dioxopiperazines from Bionectra byssicola

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In the course of our screening for new antibacterials from microbial metabolites, two new dioxopiperazine metabolites, glioperazines B (1) and C (2), together with the known compound, glioperazine (3), were isolated from the mycelia of a liquid fermentation culture of the fungus, Bionectra byssicola F120. The structures of compounds 1 and 2 were assigned on the basis of MS and NMR data. Compound 1 is an unusual dioxopiperazine metabolite containing an OMe group at the α-carbon of the amino acid residue. Compound 1 showed weak antibacterial activity against various strains of S. aureus, including methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), while 2 and 3 did not show such activity.

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