<i>Propionibacterium Acnes</i>Acts as an Adjuvant in<i>in Vitro</i>Immunization of Human Peripheral Blood Mononuclear Cells

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  • JUNG Yeon Suk
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
  • MATSUMOTO Shin-ei
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
  • YAMASHITA Makiko
    Graduate School of Systems Life Sciences, Kyushu University
  • TOMIMATSU Kosuke
    Graduate School of Systems Life Sciences, Kyushu University
  • TERUYA Kiichiro
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University Graduate School of Systems Life Sciences, Kyushu University
  • KATAKURA Yoshinori
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University Graduate School of Systems Life Sciences, Kyushu University
  • SHIRAHATA Sanetaka
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University Graduate School of Systems Life Sciences, Kyushu University

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  • Propionibacterium Acnes Acts as an Adjuvant in in Vitro Immunization of Human Peripheral Blood Mononuclear Cells
  • Propionibacterium acnes acts as an adjuvant in vitro immunization on human peripheral blood mononuclear cells

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We have established an in vitro immunization protocol whereby human peripheral blood mononuclear cells (PBMCs) are initially treated with L-leucyl-L-leucine methyl ester (LLME) and subsequently sensitized with antigen in the presence of interleukin (IL)-2, IL-4, and adjuvant. This protocol resulted in the production of antigen-specific antibodies. PBMCs are potentiated to react with exogenous antigens upon treatment with LLME. We are using this system to investigate the immunomodulatory activity of additives. In the present study, we aimed to evaluate the immunomodulatory activity of Propionibacterium acnes (P. acnes), which is known to exhibit various immunomodulatory effects in murine models, using this in vitro immunization protocol. P. acnes was found to augment the production of antigen-specific antibodies by PBMC, possibly through increased production of inflammatory cytokines and/or increased T-B cell interaction. P. acnes hence appears to act as an adjuvant in the antibody response in in vitro immunization.

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