Clinical Effects of a Hop Water Extract on Japanese Cedar Pollinosis during the Pollen Season: A Double-Blind, Placebo-Controlled Trial
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- SEGAWA Shuichi
- Frontier Laboratories of Value Creation, Sapporo Breweries Ltd.
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- TAKATA Yoshihiro
- Frontier Laboratories of Value Creation, Sapporo Breweries Ltd.
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- WAKITA Yoshihisa
- Frontier Laboratories of Value Creation, Sapporo Breweries Ltd.
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- KANEKO Takafumi
- Frontier Laboratories of Value Creation, Sapporo Breweries Ltd.
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- KANEDA Hirotaka
- Frontier Laboratories of Value Creation, Sapporo Breweries Ltd.
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- WATARI Junji
- Frontier Laboratories of Value Creation, Sapporo Breweries Ltd.
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- ENOMOTO Tatsuko
- Enomoto Otolaryngology Clinic
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- ENOMOTO Tadao
- Department of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center
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The clinical effects of an oral administration of a hop water extract (HWE) on the improvement of Japanese cedar pollinosis (JCPsis) symptoms were investigated. In a double-blind, placebo-controlled trial, 39 subjects took a drink containing either 100 mg of HWE or a placebo for 12 weeks during the pollen season. Nasal symptoms (sneezing attacks, nasal discharge, and nasal obstruction) were assessed from the subjects’ diaries. A clinical examination and blood sampling were carried out before and 4, 8 and 12 weeks after the initiation of treatment. As a result, a significant difference was observed in the symptom score and in the symptom-medication score 10 weeks after the intervention in comparison with the placebo group. Improvements were observed in nasal swelling, nasal color, amount of nasal discharge, and characteristics of nasal discharge in the intervention group 12 weeks after the treatment. No significant eosinophil infiltration into the nasal discharge was apparent in the intervention group throughout the study period, although it was observed in the placebo group. These findings indicate that an oral administration of HWE may be effective in alleviating the allergic symptoms related to JCPsis.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 71 (8), 1955-1962, 2007
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681455793536
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- NII論文ID
- 10027517698
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8887522
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
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