Assessment of Prion Inactivation by Fenton Reaction Using Protein Misfolding Cyclic Amplification and Bioassay

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  • SUYAMA Kyozo
    Sports Nutrition Department, Sendai University
  • YOSHIOKA Miyako
    Prion Disease Research Center, National Institute of Animal Health
  • AKAGAWA Mitsugu
    Department of Biological Chemistry, Division of Applied Life Science, Graduate School of Life and Environmental Science, Osaka Prefecture University
  • MURAYAMA Yuichi
    Prion Disease Research Center, National Institute of Animal Health
  • HORII Hiroko
    Prion Disease Research Center, National Institute of Animal Health
  • TAKATA Masuhiro
    Prion Disease Research Center, National Institute of Animal Health
  • YOKOYAMA Takashi
    Prion Disease Research Center, National Institute of Animal Health
  • MOHRI Shirou
    Prion Disease Research Center, National Institute of Animal Health

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An abnormal isoform of the prion protein, associated with transmissible spongiform encephalopathies, retains infectivity even after undergoing routine sterilization processes. We found that a formulation of iron ions combined with hydrogen peroxide effectively reduced infectivity and the level of abnormal isoforms of the prion protein in scrapie-infected brain homogenates. Therefore, the Fenton reaction has potential for prion decontamination.

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