Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

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  • SHIMADA Masaya
    Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, COE Program for the 21st Century, University of Shizuoka
  • MOCHIZUKI Kazuki
    Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, COE Program for the 21st Century, University of Shizuoka
  • SAKURAI Naoko
    Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, COE Program for the 21st Century, University of Shizuoka
  • GODA Toshinao
    Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, COE Program for the 21st Century, University of Shizuoka

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Epigallocatechin gallate (EGCG) reportedly enhances plasma adiponectin levels in models of insulin resistance and obesity. In this study, we found that EGCG increases plasma adiponectin levels and decreases plasma triacylglycerol levels in non-obese diabetic Goto-Kakizaki rats with insulin secretory dysfunction. These results suggest that EGCG ameliorates lipid metabolic abnormality even in non-obese rats, probably by increasing adiponectin production.

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