Okicamelliaside, an Extraordinarily Potent Anti-Degranulation Glucoside Isolated from Leaves of<i>Camellia japonica</i>

  • ONODERA Ken-ichi
    Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center
  • TSUHA Keiko
    Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center
  • YASUMOTO-HIROSE Mina
    Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center
  • TSUHA Kazuyo
    Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center
  • HANASHIRO Kaoru
    Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center
  • NAOKI Hideo
    Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center
  • YASUMOTO Takeshi
    Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center

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  • Okicamelliaside, an Extraordinarily Potent Anti-Degranulation Glucoside Isolated from Leaves of Camellia japonica

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Guided by anti-degranulation assays, we isolated from leaves of Camellia japonica an ellagic acid glucoside named okicamelliaside. The structure was elucidated as 3,4-dioxoloellagic acid 4′-O-β-D-glucopyranoside by spectroscopic and chemical methods. Okicamelliaside was 12,000 times more potent than the antihistaminic drug, ketotifen fumarate, in inhibiting the degranulation of RBL-2H3 cells.

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