Multiple Functions of the S-Phase Checkpoint Mediator
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- TANAKA Katsunori
- Department of Bioscience, School of Science and Technology, Kwansei Gakuin University Research Center for Environmental Bioscience, School of Science and Technology, Kwansei Gakuin University
Bibliographic Information
- Other Title
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- Award reviews: Multiple functions of the S-phase checkpoint mediator
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Abstract
There is mounting evidence that replication defects are the major source of spontaneous genomic instability in cells, and that S-phase checkpoints are the principal defense against such instability. The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase. In this review, the multiple functions and the regulation of the S-phase checkpoint mediator are discussed.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (12), 2367-2373, 2010
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681456004992
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- NII Article ID
- 10027727602
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- NII Book ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3M%2FntVGltA%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 10928465
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- PubMed
- 21150122
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed